Afatinib is a second-generation epidermal growth factor receptor (EGFR) inhibitor that has been shown to be effective against EGFR-mutated non-small cell lung cancer (NSCLC) resistant to conventional EGFR inhibitors such as gefitinib and erlotinib.Although ocular side effects of gefitinib and erlotinib have been reported, those for afatinib have ye
RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus.Disruption of this pathway is widely observed in cancer and other pathologies.Consequently, considerable effort has been devoted to understanding the mechanistic aspects of RAS-MAPK signal transmission and regulation.While much information has been garnered on the cl
There is higher energy in the protein content than in other weaning foods; sorghum and millets are utilized as weaning food in Ethiopia, India, Tanzania, Uganda, and several other African countries.Traditional beverages and giant beers made from sorghum seeds have more nutrients than beers made using malt.The chemical composition and mycoflora of d
The rise of conservative politicians with authoritarian attitudes, not only in Brazil, but in several socialstudiesscholar.com countries around the world, may be part of the cultural backlash of a social group unhappy with recent cultural changes.These leaders who are not able to exercise democratic governance are in line with the increase in polit
Absorption heat pumps have emerged as a potential tool to address the 100w products energy crisis because of their ability to utilize low-grade heat.The performance of an absorption heat pump largely depends on the efficiency of the working pair to operate at the source temperature.The commercialized working pairs H2O/LiBr and NH3/H2O linger with o